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Case Challenge Review – Lipoprotein A and venous thromboembolism

March 18, 2013 9:52 pm / Leave a Comment / kirschj

photo 3Summary of Findings:

  • 52yo M
  • No known PMH
  • Acute multifocal strokes (mostly cortical)
  • Significant coronary atherosclerotic disease and a dilated LV with EF<25% and multi-wall hypokinesis
  • Pulmonary emboli inflatable slide
  • Mildly elevated troponins and significantly elevated lipoprotein A

LIPOPROTEIN A AND VENOUS THROMBOEMBOLISM

Elevated lipoprotein(a) [Lp(a)] levels are a recognized risk factor for cardiovascular disease. While some studies have shown that  an elevated Lp(a) level is an independent risk factor for venous thromboembolism in adultsAufblasbare Pools, suggesting that it may be involved in the pathogenesis of idiopathic and recurrent disease, other studies have found the risk of venous thromboembolism (VTE) in adults contradictory.princess playhouse bouncy castle

 

References:

  1. Grifoni E, Marcucci R, Ciuti G, Cenci C, Poli D, Mannini L, Liotta AA, Miniati M, Abbate R, Prisco D. The thrombophilic pattern of different clinical manifestations of venous thromboembolism: a survey of 443 cases of venous thromboembolism. Semin Thromb Hemost. 2012 Mar;38(2):230-4
  2. Marcucci R, Liotta AA, Cellai AP, Rogolino A, Gori AM, Giusti B, Poli D, Fedi S, Abbate R, Prisco D. Increased plasma levels of lipoprotein(a) and the risk of idiopathic and recurrent venous thromboembolism. Am J Med. 2003 Dec 1;115(8):601-5.

 

Case is courtesy of Claudio Smuclovisky, MD

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